A semiclosed-loop optimal control system for blood glucose level in diabetics.
نویسندگان
چکیده
In this manuscript, the well-known Bergman nonlinear mathematical model of the plasma glucose/insulin interaction is adopted and a semi closed-loop optimal technique is proposed for the correction of hyperglycemia in diabetic subjects. Computer simulations are used to evaluate the effectiveness of the proposed technique and to demonstrate its superiority in controlling hyperglycemia over other existing algorithms.
منابع مشابه
A simulation study of an inverse controller for closed- and semiclosed-loop control in type 1 diabetes.
BACKGROUND Closed-loop control algorithms in diabetes aim to calculate the optimum insulin delivery to maintain the patient in a normoglycemic state, taking the blood glucose level as the algorithm's main input. The major difficulties facing these algorithms when applied subcutaneously are insulin absorption time and delays in measurement of subcutaneous glucose with respect to the blood concen...
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عنوان ژورنال:
- Journal of medical engineering & technology
دوره 28 5 شماره
صفحات -
تاریخ انتشار 2004